The Exercise-Induced Improvement in Hyperglycemia is Mediated by DHT Produced in the Skeletal Muscle of Zucker Diabetic Fatty Rats

نویسندگان

  • Koji Sato
  • Satoshi Fujita
  • Hideki Yamauchi
  • Yoko Shiroya
  • Hiromi Kitamura
  • Kumiko Minato
  • Motoyuki Iemitsu
چکیده

The beneficial effects of exercise on type 2 diabetics have been welldocumented, including restoration of glycemic control [1-3]. At the molecular level, an increase in the translocation of glucose transporter 4 (GLUT-4) following the activation of phosphatidylinositol 3-kinase (PI3-kinase), and protein kinases B (Akt) and C ζ/λ (PKCζ/λ) improves glycemic control [4,5]. Thus, chronic exercise prevents or improves type 2 diabetes.

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تاریخ انتشار 2013